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How and where to order Azelex (Azelaic Acid) cream 20% 15 g tubes online:


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Type:Azelaic Acid brand, Aziderm brand, Azelex generic
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Azelaic Acid (trade names include Azelex, Azelan, Azelderm, Aziderm, Cutacelan, Finacea, Skinoren) is an anti-acne medication for topical use from dicarboxylic acids pharmacological group. This medication is used to treat various forms of mild to moderate acne, comedonal acne, inflammatory acne, spots, pustules, rosacea (on-going skin redness with pimples), skin pigmentation including melasma and postinflammatory hyperpigmentation. Azelaic Acid works by killing acne bacteria that infect skin pores and by decreases the production of keratin, which is a natural substance that promotes the growth of acne bacteria.


Azelex (Azelaic Acid)


Related medications:

  • Adapalene (Differin)
  • Aluminium Chloride (Hemodent)
  • Aluminum Oxide (Brasivol)
  • Benzoyl Peroxide (Benzac)
  • Betamethasone (Betnovate)
  • Cefdinir (Omnicef)
  • Cephalexin (Phexin)
  • Clindamycin (Cleocin)
  • Crotamiton (Eurax)
  • Dapsone (Aczone)
  • Dexamethasone (Decadron)
  • Fusidic Acid (Fucidin)
  • Isotretinoin (Accutane)
  • Methylprednisolone (Medrol)
  • Minocycline (Minomycin)
  • Mometasone (Elocon)
  • Motretinide (Tasmaderm)
  • Mupirocin (Bactroban)
  • Permethrin (Acticin, Elimite)
  • Prednisolone (Millipred)
  • Prednisone (Deltasone)
  • Resorcinol (Astriderm)
  • Retinol (Vitamin A)
  • Tretinoin (Renova, Retin-A)


    Pharmacological and medical categories:

  • Acne treatment preparations
  • Dicarboxylic Acids derivatives
  • Skin care medications


    ATC codes:

  • D - Dermatologicals
  • D10 - Anti-acne preparations
  • D10A - Anti-acne preparations for topical use
  • D10AX - Other anti-acne preparations for topical use
  • D10AX03 - Azelaic Acid


    ICD-10 codes:

  • Seborrhoeic dermatitis - L21
  • Acne - L70
  • Rosacea - L71
  • Other disorders of pigmentation - L81


    Indications and usage:

    Azelex (Azelaic Acid) topical cream is indicated for the topical treatment of mild-to-moderate inflammatory acne vulgaris.


    Contraindications:

    Azelaic Acid (Azelex) cream is contraindicated in individuals who have shown hypersensitivity to any of its components.


    Dosage and administration:

    After the skin is thoroughly washed and patted dry, a thin film of Azelex (Azelaic Acid) cream 20% should be gently but thoroughly massaged into the affected areas twice daily, in the morning and evening. The hands should be washed following application. The duration of use of Azelex can vary from person to person and depends on the severity of the acne. Improvement of the condition occurs in the majority of patients with inflammatory lesions within four weeks.


    Warnings:

    Azelex cream is for dermatologic use only and not for ophthalmic use.

    There have been isolated reports of hypopigmentation after use of azelaic acid. Since azelaic acid has not been well studied in patients with dark complexions, these patients should be monitored for early signs of hypopigmentation.


    Precautions:

    If sensitivity or severe irritation develop with the use of Azelex (Azelaic Acid) cream topical, treatment should be discontinued and appropriate therapy instituted.


    Side effects, adverse reactions:

    During U.S. clinical trials with Azelex (Azelaic Acid) toppical cream 20%, adverse reactions were generally mild and transient in nature. The most common adverse reactions occurring in approximately 1-5% of patients were pruritus, burning, stinging and tingling. Other adverse reactions such as erythema, dryness, rash, peeling, irritation, dermatitis, and contact dermatitis were reported in less than 1% of subjects. There is the potential for experiencing allergic reactions with use of Azelex cream.

    In patients using azelaic acid formulations, the following additional adverse experiences have been reported rarely: worsening of asthma, vitiligo depigmentation, small depigmented spots, hypertrichosis, reddening (signs of keratosis pilaris), and exacerbation of recurrent herpes labialis.


    Information for patients:

    Patients should be told:

  • To use Azelex (Azelaic Acid) toppical cream 20% for the full prescribed treatment period.
  • To avoid the use of occlusive dressings or wrappings.
  • To keep this medication away from the mouth, eyes and other mucous membranes. If it does come in contact with the eyes, they should wash their eyes with large amounts of water and consult a physician if eye irritation persists.
  • If they have dark complexions, to report abnormal changes in skin color to their physician.
  • Due in part to the low pH of azelaic acid, temporary skin irritation (pruritus, burning, or stinging) may occur when Azelex cream is applied to broken or inflamed skin, usually at the start of treatment. However, this irritation commonly subsides if treatment is continued. If it continues, Azelex cream should be applied only once-a-day, or the treatment should be stopped until these effects have subsided. If troublesome irritation persists, use should be discontinued, and patients should consult their physician.


    Use in specific populations:

    Pregnancy

    Teratogenic effects: embryotoxic effects were observed in Segment I and Segment II oral studies with rats receiving 2500 mg/kg/day of azelaic acid. Similar effects were observed in Segment II studies in rabbits given 150 to 500 mg/kg/day and in monkeys given 500 mg/kg/day. The doses at which these effects were noted were all within toxic dose ranges for the dams. No teratogenic effects were observed. There are, however, no adequate and well-controlled studies in pregnant women. Because animal reproduction studies are not always predictive of human response, this drug should be used during pregnancy only if clearly needed.

    Nursing Mothers

    Equilibrium dialysis was used to assess human milk partitioning in vitro. At an azelaic acid concentration of 25 mcg/mL, the milk/plasma distribution coefficient was 0.7 and the milk/buffer distribution was 1.0, indicating that passage of drug into maternal milk may occur. Since less than 4% of a topically applied dose is systemically absorbed, the uptake of azelaic acid into maternal milk is not expected to cause a significant change from baseline azelaic acid levels in the milk. However, caution should be exercised when Azelex cream is administered to a nursing mother.

    Pediatric Use

    Safety and effectiveness in pediatric patients under 12 years of age have not been established.

    Geriatric Use

    Clinical studies of Azelaic Acid (Azelex) cream did not include sufficient numbers of subjects aged 65 and over to determine whether they respond differently from younger subjects.


    Pregnancy categories:

  • B - Australia
  • B - United States (No evidence of risk in humans)


    Salts and other forms:

  • Azelaic Acid Base


    Synonyms, international and chemical names:

  • 1,7-Heptanedicarboxylic Acid
  • 1,9-Nonanedioic Acid
  • Acide Azelaique
  • Acido Azelaico
  • Acidum Azelaicum
  • Anchoic Acid
  • Azalaic Acid
  • Azelaic Acid Polyanhydride
  • Azelaic Acid, Technical Grade
  • Azelaic Polyanhydride
  • Azelaicacidtech
  • Azelainezuur
  • Azelainic Acid
  • Azelainsaure
  • Azelainsav
  • Azelainska Kiselina
  • Azelainskabe
  • Azelainsyra
  • Azelayc Acid
  • Azilaic Acid
  • Heptanedicarboxylic Acid
  • Kwas Azelainowy
  • Kyselina Azelaova
  • Lepargylic Acid
  • N-Nonanedioic Acid
  • Nonanedioic Acid
  • Polyazelaic Anhydride


    Brands, generics, trade names:

  • Acnezaic - Pfizer
  • Azelan - Bayer
  • Azelderm - Kleva
  • Azelex - Allergan, Actavis, Bayer
  • Aziderm - Micro Labs
  • Cutacelan - Bayer
  • Finacea - Bayer, Berlex Laboratories, Intendis, LEO Pharma, Valeant Pharmaceuticals
  • Finevin - Berlex Laboratories
  • Skinoderm - Perrigo, Pharma-Clal
  • Skinorem - Bayer
  • Skinoren - Bayer, Intendis, Invida, Valeant Pharmaceuticals
  • Zelface - Ferron
  • Zeliderm - Vinas
  • Zeliris - Caprifarmindo Laboratories


    APIs used in medicine in combinations with azelaic acid:

  • Alcohol
  • Butylene Glycol
  • Camellia Sinensis
  • Citric Acid
  • Citrus Aurantium Dulcis Fruit Extract
  • Coconut Oil Hydrogenated
  • Glycerol
  • Glycolic Acid
  • Jaluramina
  • Lactic Acid
  • Malic Acid
  • Minoxidil
  • Morus Bombycis
  • Phenoxyethanol
  • Phosphatidylcholine
  • Polyacrylamide
  • Potassium Azeloyl Diglycinate
  • Prunus Armeniaca Kenel Oil
  • Saxifraga Sarmentosa
  • Scutellaria Baicalensis
  • Titanium Dioxide
  • Tretinoin
  • Vitis Vinifera


    Here is a list of popular medications containing azelaic acid as a main active pharmaceutical ingredient; their trade names, forms, doses, companies - manufacturers, distributors, suppliers, researchers and developers:

    Trade name of the drug Pharmaceutical forms and doses Companies
    Azelex
  • Cream; Topical; Azelaic Acid 20%
  • Allergan
  • Actavis
  • Bayer
  • Aziderm
  • Cream; Topical; Azelaic Acid 10%
  • Cream; Topical; Azelaic Acid 20%
  • Micro Labs
  • Cutacelan
  • Cream; Topical; Azelaic Acid 20%
  • Bayer
  • Finacea
  • Gel; Topical; Azelaic Acid 15%
  • Bayer
  • Berlex Laboratories
  • Intendis
  • LEO Pharma
  • Valeant Pharmaceuticals
  • Skinoren
  • Cream; Topical; Azelaic Acid 20%
  • Gel; Topical; Azelaic Acid 15%
  • Bayer
  • HE Clissmann
  • Intendis
  • Invida
  • The Glory Medicina
  • Valeant Pharmaceuticals
  • Zuellig Pharma



  • References:

  • Azelaic Acid main article on Wikipedia: https://en.wikipedia.org/wiki/Azelaic_acid
  • Azelaic Acid compound on PubChem: https://pubchem.ncbi.nlm.nih.gov/compound/Azelaic-acid
  • Azelaic Acid medicine on DrugBank: https://go.drugbank.com/drugs/DB00548
  • Azelaic Acid Topical FAQ on MedlinePlus (revised 12/15/2016): https://medlineplus.gov/druginfo/meds/a603020.html
  • Azelex (Azelaic Acid) cream drug label on DailyMed (revised June 11, 2012): https://dailymed.nlm.nih.gov/dailymed/drugInfo...
  • Azelaic Acid Glenmark gel drug label on DailyMed (revised January 27, 2021): https://dailymed.nlm.nih.gov/dailymed/drugInfo...
  • Finacea (Azelaic Acid) gel drug label on DailyMed (revised August 31, 2010): https://dailymed.nlm.nih.gov/dailymed/drugInfo...
  • Azelex (Azelaic Acid) cream 20% official prescribing information from the U.S. FDA (revised June 5, 2003): https://www.accessdata.fda.gov/drugsatfda_docs/label/...
  • Finacea (Azelaic Acid) gel 15% official prescribing information from the U.S. FDA (Revised July 2010): https://www.accessdata.fda.gov/drugsatfda_docs/label/...
  • Azelex (Azelaic Acid) cream 20% prescribing information from Allergan pharmaceutical company (revised 09/2015): https://media.allergan.com/actavis/actavis/media/...
  • Azelaic Acid containing drugs on Drugs-About.com: https://drugs-about.com/ing/azelaic-acid.html
  • Azelaic Acid for sale on Pharma Doctor: https://pharma-doctor.com/azelaic-acid.html
  • Finacea (Azelaic Acid) foam 15% official website: http://www.finaceafoam.com/
  • Finacea (Azelaic Acid) gel 15% patient information leaflet from Medicines.org.uk (revised November 2019): https://www.medicines.org.uk/emc/files/pil.240.pdf

    Revised: April 2021

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